| 20. Round | 19/06/2022 | Al Ahly SC | - | Zamalek | 2:2 | ||||
| 22. Round | 22/06/2022 | National Bank SC | - | Zamalek | 1:2 |  |
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| 23. Round | 28/06/2022 | Zamalek | - | Ceramica Cleopatra | 3:2 | ||||
| 24. Round | 12/07/2022 | Zamalek | - | Al Mokawloon | 1:0 |  |
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| 25. Round | 16/07/2022 | Ghazl Al Mehalla | - | Zamalek | 0:2 | ||||
| 26. Round | 24/07/2022 | Zamalek | - | Smouha Sporting Club | 2:0 | ||||
| 27. Round | 28/07/2022 | Future FC | - | Zamalek | 0:1 | ||||
| 28. Round | 01/08/2022 | Zamalek | - | Pyramids FC | 3:0 | ||||
| 29. Round | 05/08/2022 | El Gouna | - | Zamalek | 1:4 | |
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| 31. Round | 19/08/2022 | Pharco FC | - | Zamalek | 0:1 | |
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| 32. Round | 23/08/2022 | Zamalek | - | Ittihad El Iskandary | 1:1 |  |
Egypt