| 16. Round | 08/02/2010 | Zamalek | - | ENPPI | 2:0 |  |
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| 18. Round | 17/02/2010 | Zamalek | - | Al Mokawloon | 1:0 | ||||
| 19. Round | 22/02/2010 | Ittihad El Iskandary | - | Zamalek | 1:2 | ||||
| 23. Round | 24/03/2010 | Zamalek | - | El Entag El Harby | 2:0 | ||||
| 24. Round | 29/03/2010 | Ghazl Al Mehalla | - | Zamalek | 0:1 | ||||
| 25. Round | 07/04/2010 | Zamalek | - | Ittihad El Shorta | 1:1 | ||||
| 26. Round | 11/04/2010 | Haras El Hodood | - | Zamalek | 2:1 | ||||
| 30. Round | 17/05/2010 | El Mansoura SC | - | Zamalek | 0:0 |
Egypt