| 1. Round | 06/11/2021 | AS Rhodos | - | Ergotelis | 1:0 | ||||
| 3. Round | 20/11/2021 | AE Kifisias | - | Ergotelis | 1:2 | ||||
| 4. Round | 24/11/2021 | Ergotelis | - | AEK Athen II | 0:0 | ||||
| 5. Round | 27/11/2021 | PS Kalamata | - | Ergotelis | 2:0 | ||||
| 9. Round | 19/12/2021 | Ergotelis | - | Asteras Vlachioti | 0:0 | ||||
| 13. Round | 12/01/2022 | Ergotelis | - | OFI Ierapetra | 1:3 | ||||
| 16. Round | 30/01/2022 | Irodotos | - | Ergotelis | 1:2 |  |
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| 17. Round | 05/02/2022 | Ergotelis | - | Levadiakos | 1:0 | ||||
| 18. Round | 13/02/2022 | Ergotelis | - | AS Rhodos | 0:1 | ||||
| 19. Round | 16/02/2022 | AO Episkopi | - | Ergotelis | 1:0 | ||||
| 12. Round | 23/02/2022 | APS Zakynthos | - | Ergotelis | 2:0 | ||||
| 22. Round | 06/03/2022 | Ergotelis | - | PS Kalamata | 2:0 |
Egypt