| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 3. Round | 06/08/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 5. Round | 17/08/2021 | Club Tijuana [U20] | - | Puebla FC [U20] | 3:0 | ||||
| 6. Round | 22/08/2021 | CF América [U20] | - | Club Tijuana [U20] | 1:1 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 17. Round | 10/11/2021 | Club Tijuana [U20] | - | CF Pachuca [U20] | 2:1 |  |
Mexico