| Preliminary | 11/03/2022 | Jorge Wilstermann | - | CD Guabirá | 4:0 | ||||
| Preliminary | 18/03/2022 | CD Guabirá | - | Jorge Wilstermann | 3:0 | ||||
| Group D | 06/04/2022 | Everton | - | Jorge Wilstermann | 1:1 |  |
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| Group D | 14/04/2022 | Jorge Wilstermann | - | Ayacucho FC | 0:2 | ||||
| Group D | 28/04/2022 | Jorge Wilstermann | - | São Paulo FC | 1:3 | |
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| Group D | 06/05/2022 | Ayacucho FC | - | Jorge Wilstermann | 0:0 | ||||
| Group D | 20/05/2022 | São Paulo FC | - | Jorge Wilstermann | 3:0 |
Colombia