| 16. Round | 08/02/2010 | Zamalek | - | ENPPI | 2:0 | ||||
| 19. Round | 22/02/2010 | Ittihad El Iskandary | - | Zamalek | 1:2 |  |
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| 17. Round | 07/03/2010 | PetroJet FC | - | Zamalek | 2:3 | ||||
| 20. Round | 11/03/2010 | Tala'ea El Gaish SC | - | Zamalek | 0:1 | ||||
| 21. Round | 15/03/2010 | Ismaily | - | Zamalek | 0:0 | |
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| 22. Round | 19/03/2010 | El Gouna | - | Zamalek | 0:1 | ||||
| 23. Round | 24/03/2010 | Zamalek | - | El Entag El Harby | 2:0 |  |
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| 24. Round | 29/03/2010 | Ghazl Al Mehalla | - | Zamalek | 0:1 | ||||
| 26. Round | 11/04/2010 | Haras El Hodood | - | Zamalek | 2:1 | ||||
| 27. Round | 16/04/2010 | Zamalek | - | Al Ahly SC | 3:3 | |
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| 28. Round | 03/05/2010 | Al Masry Club | - | Zamalek | 1:3 | ||||
| 29. Round | 13/05/2010 | Zamalek | - | Asyut Petroleum | 4:1 | ||||
| 30. Round | 17/05/2010 | El Mansoura SC | - | Zamalek | 0:0 |
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