5. Round | 08/08/2021 | Minnesota United FC | - | Houston Dynamo | 2:0 | ||||
6. Round | 12/09/2021 | Houston Dynamo | - | Austin FC | 3:0 | ||||
7. Round | 21/10/2021 | Houston Dynamo | - | Los Angeles Galaxy | 0:3 | ||||
7. Round | 24/10/2021 | Austin FC | - | Houston Dynamo | 2:1 | ||||
7. Round | 31/10/2021 | Houston Dynamo | - | Colorado Rapids | 0:1 | ||||
8. Round | 03/11/2021 | CF Montréal | - | Houston Dynamo | 2:0 |