| 2. Round | 16/01/2022 | LD Alajuelense | - | Guadalupe | 1:0 | ||||
| 5. Round | 10/02/2022 | LD Alajuelense | - | CS Cartaginés | 3:2 | ||||
| 6. Round | 13/02/2022 | LD Alajuelense | - | Deportivo Saprissa | 0:1 | ||||
| 1. Round | 17/02/2022 | Sporting FC | - | LD Alajuelense | 2:1 | ||||
| 7. Round | 20/02/2022 | Jicaral | - | LD Alajuelense | 0:3 | ||||
| 8. Round | 26/02/2022 | LD Alajuelense | - | Municipal Grecia | 1:0 | ||||
| 9. Round | 03/03/2022 | CS Herediano | - | LD Alajuelense | 1:1 |  |
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| 12. Round | 06/04/2022 | LD Alajuelense | - | Sporting FC | 1:1 | ||||
| 13. Round | 11/04/2022 | Guadalupe | - | LD Alajuelense | 0:2 | ||||
| 14. Round | 16/04/2022 | AD Guanacasteca | - | LD Alajuelense | 0:3 | ||||
| 15. Round | 20/04/2022 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:1 | ||||
| 16. Round | 24/04/2022 | CS Cartaginés | - | LD Alajuelense | 1:2 | ||||
| 17. Round | 28/04/2022 | Deportivo Saprissa | - | LD Alajuelense | 2:0 |  |
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| 18. Round | 01/05/2022 | LD Alajuelense | - | Jicaral | 3:0 | ||||
| 19. Round | 04/05/2022 | Municipal Grecia | - | LD Alajuelense | 1:1 | ||||
| 20. Round | 09/05/2022 | LD Alajuelense | - | CS Herediano | 2:1 | ||||
| 21. Round | 13/05/2022 | LD Alajuelense | - | AD San Carlos | 1:0 |
Costa Rica