| 1. Round | 12/02/2022 | Atlético San Miguel | - | Fénix | 0:2 | ||||
| 3. Round | 26/02/2022 | Armenio | - | Atlético San Miguel | 1:1 | ||||
| 4. Round | 05/03/2022 | Atlético San Miguel | - | Dock Sud | 0:1 |  |
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| 5. Round | 12/03/2022 | UAI Urquiza | - | Atlético San Miguel | 2:0 | ||||
| 6. Round | 20/03/2022 | Atlético San Miguel | - | Villa San Carlos | 2:1 |  |
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| 7. Round | 26/03/2022 | Defensores Unidos de Zárate | - | Atlético San Miguel | 2:1 | ||||
| 8. Round | 02/04/2022 | Atlético San Miguel | - | Talleres (RdE) | 0:1 | ||||
| 9. Round | 09/04/2022 | Deportivo Merlo | - | Atlético San Miguel | 2:0 | ||||
| 10. Round | 16/04/2022 | Atlético San Miguel | - | Colegiales de Munro | 0:1 | |
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| 11. Round | 24/04/2022 | Acassuso | - | Atlético San Miguel | 2:1 | ||||
| 12. Round | 02/05/2022 | Atlético San Miguel | - | Argentino de Quilmes | 1:0 | |
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| 13. Round | 08/05/2022 | Justo José de Urquiza | - | Atlético San Miguel | 3:0 | ||||
| 14. Round | 14/05/2022 | Atlético San Miguel | - | Cañuelas | 1:1 | |
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| 15. Round | 22/05/2022 | Comunicaciones de Buenos Aires | - | Atlético San Miguel | 2:3 | ||||
| 16. Round | 28/05/2022 | Atlético San Miguel | - | CA Los Andes | 1:1 | ||||
| 17. Round | 04/06/2022 | Ituzaingó | - | Atlético San Miguel | 1:0 |
Argentina