| 1. Round | 13/03/2021 | MFK Zemplín Michalovce | - | FC Nitra | 1:1 | ||||
| 2. Round | 20/03/2021 | MFK Ružomberok | - | MFK Zemplín Michalovce | 2:0 |  |
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| 4. Round | 10/04/2021 | MFK Zemplín Michalovce | - | FK Pohronie | 1:2 | ||||
| 5. Round | 17/04/2021 | ŠKF Sereď | - | MFK Zemplín Michalovce | 2:0 | ||||
| 6. Round | 24/04/2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 7. Round | 01/05/2021 | MFK Zemplín Michalovce | - | MFK Ružomberok | 2:1 |  |
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| 9. Round | 15/05/2021 | MFK Zemplín Michalovce | - | ŠKF Sereď | 2:2 | ||||
| 10. Round | 22/05/2021 | FC Nitra | - | MFK Zemplín Michalovce | 0:4 | |
Spain