| 8. Round | 09/02/2022 | ENPPI | - | Misr lel-Maqasah SC | 0:0 |  |
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| 9. Round | 16/02/2022 | Pharco FC | - | ENPPI | 1:0 | ||||
| 10. Round | 22/02/2022 | ENPPI | - | Ittihad El Iskandary | 1:0 | ||||
| 12. Round | 08/03/2022 | ENPPI | - | El Sharkia Lel Dokhan | 1:2 | |
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| 14. Round | 14/04/2022 | Tala'ea El Gaish SC | - | ENPPI | 1:1 | ||||
| 16. Round | 26/04/2022 | Ismaily | - | ENPPI | 0:2 | ||||
| 17. Round | 29/04/2022 | ENPPI | - | National Bank SC | 2:2 | ||||
| 21. Round | 28/05/2022 | Smouha Sporting Club | - | ENPPI | 1:1 | ||||
| 23. Round | 29/06/2022 | Pyramids FC | - | ENPPI | 1:0 | ||||
| 24. Round | 13/07/2022 | ENPPI | - | El Gouna | 2:2 | ||||
| 25. Round | 18/07/2022 | Misr lel-Maqasah SC | - | ENPPI | 0:2 | ||||
| 26. Round | 22/07/2022 | ENPPI | - | Pharco FC | 0:1 | ||||
| 27. Round | 26/07/2022 | Ittihad El Iskandary | - | ENPPI | 2:1 | ||||
| 28. Round | 30/07/2022 | ENPPI | - | Al Masry Club | 1:1 | ||||
| 29. Round | 04/08/2022 | El Sharkia Lel Dokhan | - | ENPPI | 0:2 | ||||
| 30. Round | 08/08/2022 | Ceramica Cleopatra | - | ENPPI | 0:0 | ||||
| 31. Round | 17/08/2022 | ENPPI | - | Tala'ea El Gaish SC | 0:1 | ||||
| 33. Round | 27/08/2022 | ENPPI | - | Ismaily | 2:0 | ||||
| 34. Round | 30/08/2022 | National Bank SC | - | ENPPI | 1:1 | |
Egypt