| 11. Round | 03/02/2021 | ENPPI | - | Pyramids FC | 3:2 | ||||
| 12. Round | 06/02/2021 | Pyramids FC | - | Tala'ea El Gaish SC | 1:0 | ||||
| 16. Round | 14/04/2021 | Pyramids FC | - | Misr lel-Maqasah SC | 1:1 | ||||
| 26. Round | 15/06/2021 | Pyramids FC | - | Smouha Sporting Club | 0:3 | ||||
| 27. Round | 01/07/2021 | Al Ahly SC | - | Pyramids FC | 2:2 | ||||
| 28. Round | 04/07/2021 | Pyramids FC | - | ENPPI | 1:1 | ||||
| 22. Round | 08/07/2021 | El Entag El Harby | - | Pyramids FC | 2:2 | ||||
| 24. Round | 16/07/2021 | Al Mokawloon | - | Pyramids FC | 0:2 | ||||
| 25. Round | 04/08/2021 | Pyramids FC | - | Ismaily | 2:2 | ||||
| 29. Round | 08/08/2021 | Tala'ea El Gaish SC | - | Pyramids FC | 1:1 | ||||
| 30. Round | 12/08/2021 | Pyramids FC | - | Al Masry Club | 0:1 | ||||
| 31. Round | 16/08/2021 | El Gouna | - | Pyramids FC | 1:2 | ||||
| 32. Round | 19/08/2021 | Pyramids FC | - | Aswan SC | 2:0 | ||||
| 34. Round | 28/08/2021 | Pyramids FC | - | Ghazl Al Mehalla | 6:0 |  |
Egypt