| 1. Round | 28/02/2021 | FC Telavi | - | FC Samtredia | 1:0 | ||||
| 2. Round | 05/03/2021 | FC Samtredia | - | Dila Gori | 0:2 | ||||
| 3. Round | 09/03/2021 | Shukura Kobuleti | - | FC Samtredia | 1:0 | ||||
| 4. Round | 13/03/2021 | Dinamo Batumi | - | FC Samtredia | 2:0 | ||||
| 5. Round | 21/03/2021 | FC Samtredia | - | Lokomotiv Tbilisi | 3:4 | ||||
| 6. Round | 02/04/2021 | Samgurali Tskhaltubo | - | FC Samtredia | 0:1 | ||||
| 7. Round | 06/04/2021 | FC Samtredia | - | Torpedo Kutaisi | 0:0 | ||||
| 8. Round | 11/04/2021 | Dinamo Tbilisi | - | FC Samtredia | 2:1 | ||||
| 10. Round | 24/04/2021 | FC Samtredia | - | FC Telavi | 2:1 | ||||
| 11. Round | 28/04/2021 | Dila Gori | - | FC Samtredia | 1:1 | ||||
| 12. Round | 08/05/2021 | FC Samtredia | - | Shukura Kobuleti | 2:2 | ||||
| 13. Round | 12/05/2021 | FC Samtredia | - | Dinamo Batumi | 0:2 | ||||
| 14. Round | 16/05/2021 | Lokomotiv Tbilisi | - | FC Samtredia | 3:1 | ||||
| 16. Round | 09/06/2021 | Torpedo Kutaisi | - | FC Samtredia | 1:1 | ||||
| 17. Round | 13/06/2021 | FC Samtredia | - | Dinamo Tbilisi | 0:2 | ||||
| 21. Round | 02/07/2021 | Shukura Kobuleti | - | FC Samtredia | 2:0 |
Azerbaijan