| 2. Round | 23/07/2021 | Defensa y Justicia II | - | Godoy Cruz II | 2:1 | ||||
| 3. Round | 27/07/2021 | Godoy Cruz II | - | Atlético Tucumán II | 2:2 | ||||
| 4. Round | 30/07/2021 | Colón de Santa Fe II | - | Godoy Cruz II | 0:0 | ||||
| 5. Round | 06/08/2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 6. Round | 13/08/2021 | Lanús II | - | Godoy Cruz II | 5:1 | ||||
| 7. Round | 20/08/2021 | Godoy Cruz II | - | Huracán II | 2:1 | ||||
| 8. Round | 26/08/2021 | Godoy Cruz II | - | Unión de Santa Fe II | 3:0 | ||||
| 10. Round | 05/09/2021 | Godoy Cruz II | - | Gimnasia de La Plata II | 3:0 | ||||
| 13. Round | 23/09/2021 | Independiente II | - | Godoy Cruz II | 0:0 | ||||
| 16. Round | 15/10/2021 | Godoy Cruz II | - | Central Córdoba SdE II | 3:0 | ||||
| 19. Round | 31/10/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 9. Round | 11/11/2021 | Vélez Sarsfield II | - | Godoy Cruz II | 3:0 | ||||
| 21. Round | 18/11/2021 | Argentinos Juniors II | - | Godoy Cruz II | 1:1 | ||||
| 22. Round | 23/11/2021 | Godoy Cruz II | - | Estudiantes II | 0:0 |
Argentina