| 1. Round | 02/08/2022 | Peñarol | - | Fénix | 0:1 |  |
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| 2. Round | 07/08/2022 | Fénix | - | Montevideo City Torque | 1:0 | ||||
| 3. Round | 11/08/2022 | Montevideo Wanderers | - | Fénix | 2:1 | |
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| 6. Round | 20/08/2022 | Fénix | - | River Plate | 1:2 | |
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| 5. Round | 26/08/2022 | Boston River | - | Fénix | 1:1 | ||||
| 4. Round | 05/09/2022 | Fénix | - | Plaza Colonia | 0:1 | ||||
| 7. Round | 11/09/2022 | Cerro Largo | - | Fénix | 1:0 | ||||
| 8. Round | 15/09/2022 | Cerrito | - | Fénix | 0:2 |  |
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| 9. Round | 20/09/2022 | Fénix | - | Defensor Sporting | 0:0 | ||||
| 10. Round | 26/09/2022 | Albion | - | Fénix | 1:1 | |
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| 11. Round | 01/10/2022 | Fénix | - | Nacional | 1:1 | ||||
| 12. Round | 08/10/2022 | Danubio | - | Fénix | 1:1 | ||||
| 13. Round | 11/10/2022 | Fénix | - | Deportivo Maldonado | 0:1 | ||||
| 14. Round | 15/10/2022 | Rentistas | - | Fénix | 1:3 | |
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| 15. Round | 23/10/2022 | Fénix | - | Liverpool | 0:3 |
Uruguay