| 8. Round | 25/10/2020 | Montpellier HSC | - | Stade de Reims | 0:4 | ||||
| 9. Round | 01/11/2020 | AS Saint-Étienne | - | Montpellier HSC | 0:1 |  |
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| 10. Round | 07/11/2020 | Girondins Bordeaux | - | Montpellier HSC | 0:2 | ||||
| 11. Round | 22/11/2020 | Montpellier HSC | - | RC Strasbourg | 4:3 | ||||
| 12. Round | 29/11/2020 | FC Lorient | - | Montpellier HSC | 0:1 | ||||
| 13. Round | 05/12/2020 | Montpellier HSC | - | Paris Saint-Germain | 1:3 | ||||
| 14. Round | 12/12/2020 | RC Lens | - | Montpellier HSC | 2:3 | ||||
| 15. Round | 16/12/2020 | Montpellier HSC | - | FC Metz | 0:2 | ||||
| 16. Round | 20/12/2020 | Stade Brestois 29 | - | Montpellier HSC | 2:2 | ||||
| 17. Round | 23/12/2020 | Montpellier HSC | - | Lille OSC | 2:3 | ||||
| 18. Round | 06/01/2021 | Olympique Marseille | - | Montpellier HSC | 3:1 | ||||
| 22. Round | 30/01/2021 | Montpellier HSC | - | RC Lens | 1:2 |
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