| 16. Round | 16/01/2022 | Egnatia Rrogozhine | - | FK Partizani | 0:3 | ||||
| 17. Round | 21/01/2022 | FK Vllaznia | - | Egnatia Rrogozhine | 1:1 | ||||
| 19. Round | 06/02/2022 | Egnatia Rrogozhine | - | FK Kukësi | 0:2 | ||||
| 21. Round | 19/02/2022 | Egnatia Rrogozhine | - | KF Skënderbeu | 2:0 | ||||
| 25. Round | 12/03/2022 | FK Partizani | - | Egnatia Rrogozhine | 2:2 |  |
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| 26. Round | 19/03/2022 | Egnatia Rrogozhine | - | FK Vllaznia | 3:0 |  |
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| 27. Round | 02/04/2022 | Dinamo Tiranë | - | Egnatia Rrogozhine | 0:2 | |
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| 28. Round | 09/04/2022 | FK Kukësi | - | Egnatia Rrogozhine | 1:1 | ||||
| 32. Round | 04/05/2022 | Egnatia Rrogozhine | - | KF Laçi | 0:2 | ||||
| 33. Round | 09/05/2022 | KF Teuta Durrës | - | Egnatia Rrogozhine | 3:1 | ||||
| 34. Round | 14/05/2022 | Egnatia Rrogozhine | - | FK Partizani | 0:1 | ||||
| 35. Round | 21/05/2022 | FK Vllaznia | - | Egnatia Rrogozhine | 3:1 | ||||
| 36. Round | 26/05/2022 | Egnatia Rrogozhine | - | Dinamo Tiranë | 1:1 |
Albania