| 1. Round | 23/07/2021 | PFC Beroe | - | Lokomotiv Sofia | 1:0 | ||||
| 2. Round | 02/08/2021 | Pirin Blagoevgrad | - | PFC Beroe | 2:3 | ||||
| 3. Round | 07/08/2021 | PFC Beroe | - | Cherno More Varna | 0:2 | ||||
| 4. Round | 14/08/2021 | Slavia Sofia | - | PFC Beroe | 3:2 | ||||
| 8. Round | 17/09/2021 | Botev Plovdiv | - | PFC Beroe | 2:1 | ||||
| 11. Round | 18/10/2021 | CSKA 1948 Sofia | - | PFC Beroe | 1:0 | ||||
| 12. Round | 24/10/2021 | PFC Beroe | - | CSKA Sofia | 0:0 |  |
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| 13. Round | 31/10/2021 | PFC Ludogorets Razgrad | - | PFC Beroe | 2:0 | ||||
| 14. Round | 05/11/2021 | Lokomotiv Sofia | - | PFC Beroe | 0:3 | ||||
| 15. Round | 19/11/2021 | PFC Beroe | - | Pirin Blagoevgrad | 1:1 | ||||
| 16. Round | 26/11/2021 | Cherno More Varna | - | PFC Beroe | 1:0 | ||||
| 17. Round | 30/11/2021 | PFC Beroe | - | Slavia Sofia | 2:1 | ||||
| 18. Round | 04/12/2021 | Botev Vratsa | - | PFC Beroe | 1:0 | ||||
| 19. Round | 12/12/2021 | PFC Beroe | - | Levski Sofia | 1:1 | ||||
| 20. Round | 20/02/2022 | Tsarsko Selo Sofia | - | PFC Beroe | 1:2 | ||||
| 21. Round | 26/02/2022 | PFC Beroe | - | Botev Plovdiv | 1:1 | |
Bulgaria