| 1. Round | 23/08/2021 | Apollon Limassol | - | Ethnikos Achna | 4:2 |  |
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| 2. Round | 11/09/2021 | Aris Limassol | - | Apollon Limassol | 0:1 | ||||
| 3. Round | 19/09/2021 | Apollon Limassol | - | APOEL Nikosia | 2:1 | ||||
| 4. Round | 26/09/2021 | AEL Limassol | - | Apollon Limassol | 0:1 | ||||
| 5. Round | 01/10/2021 | Apollon Limassol | - | AEK Larnaca | 1:4 | |
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| 6. Round | 17/10/2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | ||||
| 7. Round | 23/10/2021 | Apollon Limassol | - | Paphos FC | 2:0 | |
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| 8. Round | 31/10/2021 | Olympiakos Nikosia | - | Apollon Limassol | 0:2 |  |
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| 9. Round | 05/11/2021 | Apollon Limassol | - | Doxa Katokopias | 3:0 | ||||
| 13. Round | 12/12/2021 | Apollon Limassol | - | Aris Limassol | 0:2 | ||||
| 18. Round | 22/01/2022 | Paphos FC | - | Apollon Limassol | 0:1 | |
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| 19. Round | 30/01/2022 | Apollon Limassol | - | Olympiakos Nikosia | 2:1 | ||||
| 20. Round | 07/02/2022 | Doxa Katokopias | - | Apollon Limassol | 0:3 | ||||
| 15. Round | 10/02/2022 | Apollon Limassol | - | AEL Limassol | 2:1 | |
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| 21. Round | 15/02/2022 | PAEEK | - | Apollon Limassol | 2:2 | ||||
| 22. Round | 26/02/2022 | Apollon Limassol | - | Anorthosis Famagusta | 2:2 |
Cyprus