| 1. Round | 01/03/2021 | FC Saburtalo | - | Lokomotiv Tbilisi | 2:0 | ||||
| 2. Round | 06/03/2021 | Lokomotiv Tbilisi | - | FC Telavi | 3:2 | ||||
| 9. Round | 16/04/2021 | Lokomotiv Tbilisi | - | Dinamo Tbilisi | 1:3 | ||||
| 13. Round | 12/05/2021 | Shukura Kobuleti | - | Lokomotiv Tbilisi | 0:1 | ||||
| 14. Round | 16/05/2021 | Lokomotiv Tbilisi | - | FC Samtredia | 3:1 | ||||
| 16. Round | 10/06/2021 | Samgurali Tskhaltubo | - | Lokomotiv Tbilisi | 1:3 | ||||
| 19. Round | 23/06/2021 | FC Saburtalo | - | Lokomotiv Tbilisi | 1:2 | ||||
| 20. Round | 27/06/2021 | Lokomotiv Tbilisi | - | FC Telavi | 2:3 | ||||
| 21. Round | 01/07/2021 | Dila Gori | - | Lokomotiv Tbilisi | 2:1 | ||||
| 23. Round | 13/08/2021 | FC Samtredia | - | Lokomotiv Tbilisi | 1:0 | ||||
| 24. Round | 16/09/2021 | Dinamo Batumi | - | Lokomotiv Tbilisi | 7:3 | ||||
| 28. Round | 03/10/2021 | Lokomotiv Tbilisi | - | FC Saburtalo | 3:2 | ||||
| 30. Round | 20/10/2021 | Lokomotiv Tbilisi | - | Dila Gori | 0:4 | ||||
| 31. Round | 24/10/2021 | Shukura Kobuleti | - | Lokomotiv Tbilisi | 0:1 | ||||
| 32. Round | 01/11/2021 | Lokomotiv Tbilisi | - | FC Samtredia | 4:2 | ||||
| 36. Round | 04/12/2021 | Dinamo Tbilisi | - | Lokomotiv Tbilisi | 3:2 |
Georgia