| 2. Round | 10/09/2021 | Persela Lamongan | - | Persipura Jayapura | 1:0 | ||||
| 3. Round | 19/09/2021 | Persipura Jayapura | - | Persija Jakarta | 0:0 | ||||
| 4. Round | 24/09/2021 | Persiraja Banda Aceh | - | Persipura Jayapura | 1:2 | ||||
| 5. Round | 29/09/2021 | Persipura Jayapura | - | Arema Cronus FC | 0:1 | ||||
| 6. Round | 03/10/2021 | Madura United | - | Persipura Jayapura | 2:2 |  |
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| 11. Round | 05/11/2021 | Persipura Jayapura | - | Bali United | 0:1 |  |
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| 16. Round | 07/12/2021 | PSS Sleman | - | Persipura Jayapura | 1:1 | ||||
| 17. Round | 11/12/2021 | Persipura Jayapura | - | PSIS Semarang | 2:1 | |
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| 18. Round | 06/01/2022 | Persipura Jayapura | - | Persela Lamongan | 1:1 | ||||
| 25. Round | 14/02/2022 | PS Barito Putera | - | Persipura Jayapura | 3:0 | ||||
| 26. Round | 18/02/2022 | Persipura Jayapura | - | Persib Bandung | 0:3 | ||||
| 27. Round | 24/02/2022 | Bali United | - | Persipura Jayapura | 4:1 |
Indonesia