| 3. Round | 30/03/2022 | Unión Magdalena | - | Real Santander | 3:1 | ||||
| 3. Round | 06/04/2022 | Real Santander | - | Unión Magdalena | 1:5 |  |
 |
||
| Round of 16 | 20/04/2022 | América de Cali | - | Unión Magdalena | 1:2 | ||||
| Round of 16 | 12/05/2022 | Unión Magdalena | - | América de Cali | 2:1 | |
|||
| Quarter-finals | 18/08/2022 | Unión Magdalena | - | La Equidad | 5:4 pso |
Colombia