| 1. Round | 22/01/2022 | Once Caldas | - | Unión Magdalena | 1:1 | ||||
| 2. Round | 27/01/2022 | Unión Magdalena | - | Alianza Petrolera | 0:0 | ||||
| 3. Round | 01/02/2022 | Deportes Tolima | - | Unión Magdalena | 2:1 | ||||
| 4. Round | 03/02/2022 | Unión Magdalena | - | Deportivo Pasto | 0:0 | ||||
| 5. Round | 06/02/2022 | Millonarios | - | Unión Magdalena | 1:0 | ||||
| 6. Round | 11/02/2022 | Unión Magdalena | - | Envigado FC | 2:1 | ||||
| 8. Round | 20/02/2022 | Atlético Nacional | - | Unión Magdalena | 1:0 | ||||
| 12. Round | 21/03/2022 | Jaguares de Córdoba | - | Unión Magdalena | 2:0 | ||||
| 15. Round | 10/04/2022 | Unión Magdalena | - | Patriotas FC | 0:1 | ||||
| 19. Round | 05/05/2022 | Unión Magdalena | - | La Equidad | 1:1 | ||||
| 20. Round | 16/05/2022 | América de Cali | - | Unión Magdalena | 1:0 |
Colombia