| 5. Round | 25/09/2020 | Lille OSC | - | FC Nantes | 2:0 | ||||
| 6. Round | 04/10/2020 | RC Strasbourg | - | Lille OSC | 0:3 | ||||
| 8. Round | 25/10/2020 | OGC Nice | - | Lille OSC | 1:1 | ||||
| 9. Round | 01/11/2020 | Lille OSC | - | Olympique Lyonnais | 1:1 | ||||
| 10. Round | 08/11/2020 | Stade Brestois 29 | - | Lille OSC | 3:2 | ||||
| 11. Round | 22/11/2020 | Lille OSC | - | FC Lorient | 4:0 | ||||
| 12. Round | 29/11/2020 | AS Saint-Étienne | - | Lille OSC | 1:1 | ||||
| 13. Round | 06/12/2020 | Lille OSC | - | AS Monaco | 2:1 | ||||
| 15. Round | 16/12/2020 | Dijon FCO | - | Lille OSC | 0:2 | ||||
| 18. Round | 06/01/2021 | Lille OSC | - | Angers SCO | 1:2 | ||||
| 19. Round | 09/01/2021 | Nîmes Olympique | - | Lille OSC | 0:1 | ||||
| 23. Round | 03/02/2021 | Girondins Bordeaux | - | Lille OSC | 0:3 | ||||
| 24. Round | 07/02/2021 | FC Nantes | - | Lille OSC | 0:2 | ||||
| 25. Round | 14/02/2021 | Lille OSC | - | Stade Brestois 29 | 0:0 | ||||
| 27. Round | 28/02/2021 | Lille OSC | - | RC Strasbourg | 1:1 |
France
Comoros