| 7. Round | 29/08/2021 | Isidro Metapán | - | Alianza | 1:2 |  |
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| 5. Round | 10/09/2021 | Alianza | - | Once Municipal | 1:0 |  |
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| 10. Round | 19/09/2021 | Alianza | - | CD Águila | 2:1 | ||||
| 11. Round | 25/09/2021 | Jocoro FC | - | Alianza | 3:3 | ||||
| 12. Round | 02/10/2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 18. Round | 06/11/2021 | Alianza | - | Isidro Metapán | 1:0 | ||||
| 19. Round | 13/11/2021 | Atlético Marte | - | Alianza | 2:1 | ||||
| 20. Round | 18/11/2021 | Alianza | - | Santa Tecla FC | 5:0 | ||||
| 21. Round | 21/11/2021 | CD Águila | - | Alianza | 0:1 | ||||
| 22. Round | 27/11/2021 | Alianza | - | Jocoro FC | 2:0 |
El Salvador