| 1. Round | 01/08/2021 | Managua FC | - | Juventus Managua | 0:1 | ||||
| 2. Round | 09/08/2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
| 4. Round | 22/08/2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 7. Round | 13/09/2021 | UNAN Managua | - | Managua FC | 2:3 |  |
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| 8. Round | 20/09/2021 | Managua FC | - | Real Madriz | 1:1 |  |
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| 6. Round | 23/09/2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
| 9. Round | 27/09/2021 | CD Walter Ferretti | - | Managua FC | 0:0 | ||||
| 11. Round | 10/10/2021 | Managua FC | - | ART Municipal Jalapa | 3:0 | ||||
| 14. Round | 25/10/2021 | Diriangén FC | - | Managua FC | 0:3 | ||||
| 15. Round | 31/10/2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
| 17. Round | 18/11/2021 | Real Madriz | - | Managua FC | 1:3 | ||||
| 18. Round | 22/11/2021 | Managua FC | - | CD Walter Ferretti | 3:1 | |
Nicaragua