| 1. Round | 12/08/2007 | 1899 Hoffenheim | - | SV Wehen Wiesbaden | 2:3 |  |
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| 2. Round | 19/08/2007 | Bor. Mönchengladbach | - | 1899 Hoffenheim | 0:0 | ||||
| 3. Round | 26/08/2007 | 1899 Hoffenheim | - | TSV 1860 München | 0:3 | ||||
| 4. Round | 03/09/2007 | SC Freiburg | - | 1899 Hoffenheim | 3:2 | ||||
| 5. Round | 16/09/2007 | 1899 Hoffenheim | - | VfL Osnabrück | 3:1 |  |
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| 6. Round | 21/09/2007 | SC Paderborn 07 | - | 1899 Hoffenheim | 0:2 | ||||
| 7. Round | 25/09/2007 | Erzgebirge Aue | - | 1899 Hoffenheim | 2:2 | ||||
| 8. Round | 30/09/2007 | 1899 Hoffenheim | - | 1. FSV Mainz 05 | 1:0 | ||||
| 9. Round | 07/10/2007 | FC Augsburg | - | 1899 Hoffenheim | 2:2 | |
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| 10. Round | 19/10/2007 | 1899 Hoffenheim | - | 1. FC Kaiserslautern | 1:0 | ||||
| 11. Round | 26/10/2007 | Alemannia Aachen | - | 1899 Hoffenheim | 2:2 | ||||
| 12. Round | 02/11/2007 | 1899 Hoffenheim | - | FC St. Pauli | 1:1 | |
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| 13. Round | 11/11/2007 | FC Carl Zeiss Jena | - | 1899 Hoffenheim | 0:1 | ||||
| 14. Round | 25/11/2007 | 1899 Hoffenheim | - | 1. FC Köln | 0:2 | ||||
| 15. Round | 02/12/2007 | TuS Koblenz | - | 1899 Hoffenheim | 2:2 | |
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| 16. Round | 09/12/2007 | 1899 Hoffenheim | - | Kickers Offenbach | 2:2 | ||||
| 17. Round | 16/12/2007 | SpVgg Greuther Fürth | - | 1899 Hoffenheim | 4:1 |
Ghana