| 1. Round | 08/08/2009 | 1899 Hoffenheim | - | Bayern München | 1:1 | ||||
| 2. Round | 15/08/2009 | Bayer Leverkusen | - | 1899 Hoffenheim | 1:0 |  |
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| 3. Round | 21/08/2009 | 1899 Hoffenheim | - | FC Schalke 04 | 0:0 | |
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| 4. Round | 29/08/2009 | Hannover 96 | - | 1899 Hoffenheim | 0:1 | ||||
| 6. Round | 19/09/2009 | Bor. Mönchengladbach | - | 1899 Hoffenheim | 2:4 | ||||
| 8. Round | 03/10/2009 | 1. FSV Mainz 05 | - | 1899 Hoffenheim | 2:1 | ||||
| 9. Round | 17/10/2009 | Werder Bremen | - | 1899 Hoffenheim | 2:0 | |
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| 11. Round | 01/11/2009 | SC Freiburg | - | 1899 Hoffenheim | 0:1 | ||||
| 12. Round | 07/11/2009 | 1899 Hoffenheim | - | VfL Wolfsburg | 1:2 | ||||
| 14. Round | 28/11/2009 | 1899 Hoffenheim | - | Borussia Dortmund | 1:2 | ||||
| 15. Round | 05/12/2009 | Hamburger SV | - | 1899 Hoffenheim | 0:0 | ||||
| 17. Round | 19/12/2009 | VfB Stuttgart | - | 1899 Hoffenheim | 3:1 | ||||
| 21. Round | 06/02/2010 | 1899 Hoffenheim | - | Hannover 96 | 2:1 | ||||
| 22. Round | 13/02/2010 | VfL Bochum | - | 1899 Hoffenheim | 2:1 | ||||
| 23. Round | 19/02/2010 | 1899 Hoffenheim | - | Bor. Mönchengladbach | 2:2 | ||||
| 24. Round | 27/02/2010 | Hertha BSC | - | 1899 Hoffenheim | 0:2 |
Ghana