| 1. Round | 20/02/2021 | San Francisco FC | - | Atlético Chiriquí | 4:4 |  |
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| 2. Round | 27/02/2021 | UD Universitario | - | San Francisco FC | 3:2 | |
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| 3. Round | 06/03/2021 | San Francisco FC | - | Independiente de La Chorrera | 0:1 | ||||
| 4. Round | 14/03/2021 | Herrera FC | - | San Francisco FC | 1:0 | ||||
| 5. Round | 17/03/2021 | San Francisco FC | - | Veraguas Club Deportivo | 1:2 | ||||
| 6. Round | 20/03/2021 | Tauro FC | - | San Francisco FC | 1:0 | ||||
| 7. Round | 23/03/2021 | San Francisco FC | - | Plaza Amador | 0:2 | ||||
| 8. Round | 27/03/2021 | San Francisco FC | - | Deportivo del Este | 2:0 | |
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| 9. Round | 04/04/2021 | Alianza | - | San Francisco FC | 1:1 | ||||
| 10. Round | 10/04/2021 | San Francisco FC | - | Sporting San Miguelito | 2:0 | |
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| 11. Round | 15/04/2021 | Árabe Unido | - | San Francisco FC | 1:1 | ||||
| 12. Round | 21/04/2021 | Atlético Chiriquí | - | San Francisco FC | 3:0 |
Panama