| 1. Round | 21/08/2020 | KMSK Deinze | - | Union Saint-Gilloise | 0:2 | ||||
| 2. Round | 30/08/2020 | Union Saint-Gilloise | - | KVC Westerlo | 0:0 | ||||
| 3. Round | 13/09/2020 | Club NXT | - | Union Saint-Gilloise | 1:1 | ||||
| 4. Round | 19/09/2020 | Union Saint-Gilloise | - | RFC Seraing | 3:2 | ||||
| 5. Round | 26/09/2020 | RWD Molenbeek | - | Union Saint-Gilloise | 3:1 | ||||
| 8. Round | 25/10/2020 | Union Saint-Gilloise | - | Club NXT | 6:0 | ||||
| 11. Round | 22/11/2020 | Union Saint-Gilloise | - | RWD Molenbeek | 2:1 | ||||
| 16. Round | 23/01/2021 | KMSK Deinze | - | Union Saint-Gilloise | 2:4 | ||||
| 19. Round | 14/02/2021 | Union Saint-Gilloise | - | Club NXT | 3:1 | ||||
| 21. Round | 27/02/2021 | Union Saint-Gilloise | - | Lommel SK | 3:2 |  |
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| 22. Round | 05/03/2021 | Lierse Kempenzonen | - | Union Saint-Gilloise | 1:3 | ||||
| 23. Round | 13/03/2021 | Union Saint-Gilloise | - | RWD Molenbeek | 2:1 | ||||
| 24. Round | 19/03/2021 | KVC Westerlo | - | Union Saint-Gilloise | 2:2 | |
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| 25. Round | 03/04/2021 | Union Saint-Gilloise | - | RFC Seraing | 2:0 | ||||
| 28. Round | 25/04/2021 | Union Saint-Gilloise | - | KMSK Deinze | 2:2 |
France