| 2. Round | 01/08/2021 | FK Ural | - | FK Nizhny Novgorod | 1:1 | ||||
| 3. Round | 07/08/2021 | Spartak Moskva | - | FK Nizhny Novgorod | 1:2 | ||||
| 11. Round | 17/10/2021 | Krylia Sovetov | - | FK Nizhny Novgorod | 2:0 | ||||
| 12. Round | 23/10/2021 | FK Nizhny Novgorod | - | FK Krasnodar | 1:4 | ||||
| 13. Round | 30/10/2021 | FK Nizhny Novgorod | - | Lokomotiv Moskva | 1:2 | ||||
| 14. Round | 07/11/2021 | Akhmat Grozny | - | FK Nizhny Novgorod | 3:1 | ||||
| 15. Round | 19/11/2021 | Zenit St. Petersburg | - | FK Nizhny Novgorod | 5:1 |  |
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| 17. Round | 05/12/2021 | FK Nizhny Novgorod | - | Rubin Kazan | 2:1 | ||||
| 18. Round | 12/12/2021 | FK Krasnodar | - | FK Nizhny Novgorod | 0:0 | |
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| 23. Round | 02/04/2022 | FK Rostov | - | FK Nizhny Novgorod | 1:2 | |
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| 25. Round | 17/04/2022 | FK Nizhny Novgorod | - | FK Khimki | 0:0 | ||||
| 27. Round | 02/05/2022 | Arsenal Tula | - | FK Nizhny Novgorod | 2:2 | ||||
| 28. Round | 07/05/2022 | FK Nizhny Novgorod | - | Akhmat Grozny | 0:1 | ||||
| 29. Round | 13/05/2022 | FK Sochi | - | FK Nizhny Novgorod | 0:0 |
Serbia
Russia