| 1. Round | 21/08/2010 | Hamburger SV | - | FC Schalke 04 | 2:1 | ||||
| 2. Round | 28/08/2010 | FC Schalke 04 | - | Hannover 96 | 1:2 | ||||
| 3. Round | 10/09/2010 | 1899 Hoffenheim | - | FC Schalke 04 | 2:0 | ||||
| 4. Round | 19/09/2010 | FC Schalke 04 | - | Borussia Dortmund | 1:3 | ||||
| 5. Round | 22/09/2010 | SC Freiburg | - | FC Schalke 04 | 1:2 |  |
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| 6. Round | 25/09/2010 | FC Schalke 04 | - | Bor. Mönchengladbach | 2:2 | ||||
| 7. Round | 02/10/2010 | 1. FC Nürnberg | - | FC Schalke 04 | 2:1 | ||||
| 9. Round | 23/10/2010 | Eintracht Frankfurt | - | FC Schalke 04 | 0:0 | ||||
| 10. Round | 30/10/2010 | FC Schalke 04 | - | Bayer Leverkusen | 0:1 | ||||
| 12. Round | 13/11/2010 | VfL Wolfsburg | - | FC Schalke 04 | 2:2 | ||||
| 13. Round | 20/11/2010 | FC Schalke 04 | - | Werder Bremen | 4:0 | ||||
| 15. Round | 04/12/2010 | FC Schalke 04 | - | Bayern München | 2:0 | ||||
| 16. Round | 12/12/2010 | 1. FSV Mainz 05 | - | FC Schalke 04 | 0:1 | ||||
| 17. Round | 18/12/2010 | FC Schalke 04 | - | 1. FC Köln | 3:0 | ||||
| 18. Round | 15/01/2011 | FC Schalke 04 | - | Hamburger SV | 0:1 | ||||
| 19. Round | 22/01/2011 | Hannover 96 | - | FC Schalke 04 | 0:1 |
Switzerland
