| 23. Round | 26/02/2021 | NK Varaždin | - | NK Osijek | 2:3 |  |
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| 24. Round | 07/03/2021 | NK Osijek | - | HNK Gorica | 1:1 | ||||
| 25. Round | 14/03/2021 | HNK Šibenik | - | NK Osijek | 0:4 | |
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| 26. Round | 19/03/2021 | NK Osijek | - | Lokomotiva Zagreb | 2:0 | ||||
| 27. Round | 03/04/2021 | NK Istra 1961 | - | NK Osijek | 0:2 | ||||
| 28. Round | 11/04/2021 | Slaven Belupo | - | NK Osijek | 2:2 | ||||
| 30. Round | 21/04/2021 | NK Osijek | - | Dinamo Zagreb | 1:1 | ||||
| 31. Round | 25/04/2021 | HNK Rijeka | - | NK Osijek | 0:0 | |
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| 32. Round | 02/05/2021 | NK Osijek | - | NK Varaždin | 1:1 | ||||
| 33. Round | 07/05/2021 | HNK Gorica | - | NK Osijek | 1:0 | ||||
| 34. Round | 11/05/2021 | NK Osijek | - | HNK Šibenik | 3:0 | |
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| 35. Round | 15/05/2021 | Lokomotiva Zagreb | - | NK Osijek | 0:2 | |
Croatia