| 18. Round | 06/12/2021 | NK Istra 1961 | - | Slaven Belupo | 1:2 | ||||
| 19. Round | 12/12/2021 | Dinamo Zagreb | - | Slaven Belupo | 3:0 | ||||
| 20. Round | 17/12/2021 | Slaven Belupo | - | Lokomotiva Zagreb | 2:1 | ||||
| 21. Round | 29/01/2022 | NK Osijek | - | Slaven Belupo | 1:2 | ||||
| 22. Round | 04/02/2022 | Slaven Belupo | - | HNK Šibenik | 1:1 | ||||
| 23. Round | 13/02/2022 | Hajduk Split | - | Slaven Belupo | 3:1 | ||||
| 24. Round | 18/02/2022 | HNK Gorica | - | Slaven Belupo | 0:3 | ||||
| 25. Round | 25/02/2022 | Slaven Belupo | - | Hrvatski Dragovoljac | 1:0 | ||||
| 26. Round | 05/03/2022 | HNK Rijeka | - | Slaven Belupo | 3:0 | ||||
| 27. Round | 12/03/2022 | Slaven Belupo | - | NK Istra 1961 | 0:0 | ||||
| 28. Round | 20/03/2022 | Slaven Belupo | - | Dinamo Zagreb | 0:1 | ||||
| 29. Round | 04/04/2022 | Lokomotiva Zagreb | - | Slaven Belupo | 3:1 | ||||
| 30. Round | 10/04/2022 | Slaven Belupo | - | NK Osijek | 0:1 | ||||
| 31. Round | 16/04/2022 | HNK Šibenik | - | Slaven Belupo | 2:1 | ||||
| 32. Round | 24/04/2022 | Slaven Belupo | - | Hajduk Split | 0:0 | ||||
| 33. Round | 30/04/2022 | Slaven Belupo | - | HNK Gorica | 2:1 | ||||
| 34. Round | 06/05/2022 | Hrvatski Dragovoljac | - | Slaven Belupo | 1:1 | ||||
| 35. Round | 14/05/2022 | Slaven Belupo | - | HNK Rijeka | 2:2 |
Croatia