| 4. Round | 13/08/2021 | Pirin Blagoevgrad | - | CSKA 1948 Sofia | 4:1 | ||||
| 6. Round | 29/08/2021 | Pirin Blagoevgrad | - | PFC Ludogorets Razgrad | 1:3 | ||||
| 16. Round | 27/11/2021 | Pirin Blagoevgrad | - | Lokomotiv Plovdiv | 2:3 | ||||
| 18. Round | 05/12/2021 | Pirin Blagoevgrad | - | CSKA Sofia | 1:1 | ||||
| 19. Round | 13/12/2021 | PFC Ludogorets Razgrad | - | Pirin Blagoevgrad | 3:5 | ||||
| 21. Round | 28/02/2022 | Pirin Blagoevgrad | - | Arda Kardzhali | 1:0 | ||||
| 22. Round | 05/03/2022 | Cherno More Varna | - | Pirin Blagoevgrad | 1:1 |  |
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| 23. Round | 14/03/2022 | Pirin Blagoevgrad | - | Slavia Sofia | 0:0 | ||||
| 24. Round | 20/03/2022 | Botev Vratsa | - | Pirin Blagoevgrad | 0:3 | ||||
| 26. Round | 11/04/2022 | Tsarsko Selo Sofia | - | Pirin Blagoevgrad | 1:0 |
Bulgaria