| 12. Round | 05/11/2021 | NK Sesvete | - | NK Opatija | 2:1 | ||||
| 13. Round | 20/11/2021 | NK Opatija | - | NK Dugopolje | 0:2 | ||||
| 14. Round | 27/11/2021 | NK Dubrava | - | NK Opatija | 1:0 | ||||
| 15. Round | 04/12/2021 | NK Opatija | - | HNK Orijent Rijeka | 0:1 | ||||
| 16. Round | 12/02/2022 | NK Opatija | - | HNK Cibalia | 2:1 | ||||
| 18. Round | 26/02/2022 | NK Opatija | - | NK Kustošija | 2:1 |  |
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| 19. Round | 06/03/2022 | NK BSK Bijelo Brdo | - | NK Opatija | 4:1 | ||||
| 20. Round | 12/03/2022 | NK Opatija | - | Dinamo Zagreb II | 0:0 | ||||
| 21. Round | 19/03/2022 | NK Solin | - | NK Opatija | 1:0 | ||||
| 22. Round | 02/04/2022 | NK Opatija | - | NK Croatia Zmijavci | 2:1 | |
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| 23. Round | 09/04/2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Round | 16/04/2022 | NK Varaždin | - | NK Opatija | 4:0 |
Croatia