| 18. Round | 13/02/2022 | Empoli FC [Youth] | - | Hellas Verona [Youth] | 2:1 | ||||
| 19. Round | 16/02/2022 | Empoli FC [Youth] | - | Delfino Pescara [Youth] | 1:2 | ||||
| 20. Round | 20/02/2022 | SPAL 2013 Ferrara [Youth] | - | Empoli FC [Youth] | 0:2 |  |
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| 21. Round | 26/02/2022 | Empoli FC [Youth] | - | Torino FC [Youth] | 1:1 |  |
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| 22. Round | 05/03/2022 | Inter [Youth] | - | Empoli FC [Youth] | 2:2 | ||||
| 23. Round | 09/03/2022 | Empoli FC [Youth] | - | AS Roma [Youth] | 1:0 | ||||
| 24. Round | 12/03/2022 | SSC Napoli [Youth] | - | Empoli FC [Youth] | 2:2 | ||||
| 25. Round | 20/03/2022 | Empoli FC [Youth] | - | US Lecce [Youth] | 2:1 | ||||
| 26. Round | 02/04/2022 | ACF Fiorentina [Youth] | - | Empoli FC [Youth] | 1:1 | ||||
| 27. Round | 10/04/2022 | Empoli FC [Youth] | - | Sampdoria [Youth] | 1:0 | ||||
| 28. Round | 13/04/2022 | Atalanta [Youth] | - | Empoli FC [Youth] | 3:2 | ||||
| 32. Round | 29/04/2022 | Empoli FC [Youth] | - | AC Milan [Youth] | 3:1 | ||||
| 33. Round | 08/05/2022 | Genoa CFC [Youth] | - | Empoli FC [Youth] | 1:1 |
Poland