| 1. Round | 08/08/2020 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:2 | ||||
| 2. Round | 11/08/2020 | Spartak Trnava | - | MFK Ružomberok | 3:1 | ||||
| 3. Round | 15/08/2020 | Spartak Trnava | - | FK Pohronie | 1:1 | ||||
| 4. Round | 22/08/2020 | FC DAC 1904 | - | Spartak Trnava | 2:1 |  |
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| 5. Round | 29/08/2020 | Spartak Trnava | - | ŠKF Sereď | 0:2 | ||||
| 6. Round | 12/09/2020 | Slovan Bratislava | - | Spartak Trnava | 2:0 | ||||
| 7. Round | 19/09/2020 | Spartak Trnava | - | Zlaté Moravce | 1:0 | ||||
| 8. Round | 26/09/2020 | FK Senica | - | Spartak Trnava | 0:2 | |
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| 9. Round | 03/10/2020 | Spartak Trnava | - | FC Nitra | 0:2 | ||||
| 10. Round | 18/10/2020 | MŠK Žilina | - | Spartak Trnava | 2:1 | ||||
| 11. Round | 24/10/2020 | Spartak Trnava | - | AS Trenčín | 2:0 | ||||
| 12. Round | 31/10/2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 | ||||
| 13. Round | 07/11/2020 | MFK Ružomberok | - | Spartak Trnava | 0:1 | ||||
| 14. Round | 21/11/2020 | FK Pohronie | - | Spartak Trnava | 3:3 |
Nigeria