| 1. Round | 01/08/2022 | Real España | - | Lobos UPNFM | 1:0 |  |
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| 2. Round | 07/08/2022 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
| 3. Round | 11/08/2022 | Victoria | - | Lobos UPNFM | 4:0 | |
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| 4. Round | 14/08/2022 | Lobos UPNFM | - | Honduras Progreso | 1:2 | ||||
| 5. Round | 21/08/2022 | Lobos UPNFM | - | Motagua | 2:3 | |
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| 6. Round | 28/08/2022 | Olimpia | - | Lobos UPNFM | 2:0 | ||||
| 7. Round | 01/09/2022 | Lobos UPNFM | - | Olancho FC | 1:2 |  |
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| 9. Round | 11/09/2022 | Vida | - | Lobos UPNFM | 2:1 | |
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| 10. Round | 18/09/2022 | Lobos UPNFM | - | Real España | 2:2 |  |
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| 11. Round | 02/10/2022 | Real Sociedad | - | Lobos UPNFM | 0:2 | |
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| 13. Round | 16/10/2022 | Honduras Progreso | - | Lobos UPNFM | 2:2 | |
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| 14. Round | 21/10/2022 | Motagua | - | Lobos UPNFM | 2:2 | |
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| 15. Round | 23/10/2022 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
| 16. Round | 06/11/2022 | Olancho FC | - | Lobos UPNFM | 3:0 | ||||
| 17. Round | 13/11/2022 | Lobos UPNFM | - | Marathón | 2:1 | ||||
| 18. Round | 19/11/2022 | Lobos UPNFM | - | Vida | 3:2 |
Honduras
Haiti