| 1. Round | 18/02/2022 | Shelbourne FC | - | St Patrick's Athletic | 0:3 | ||||
| 2. Round | 25/02/2022 | St Patrick's Athletic | - | Sligo Rovers | 1:2 | ||||
| 3. Round | 28/02/2022 | Bohemian FC | - | St Patrick's Athletic | 1:0 | ||||
| 4. Round | 04/03/2022 | St Patrick's Athletic | - | Shamrock Rovers | 1:0 |  |
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| 5. Round | 11/03/2022 | Finn Harps | - | St Patrick's Athletic | 0:2 |  |
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| 6. Round | 14/03/2022 | St Patrick's Athletic | - | UC Dublin | 2:0 | ||||
| 7. Round | 18/03/2022 | Derry City | - | St Patrick's Athletic | 2:1 | ||||
| 8. Round | 01/04/2022 | St Patrick's Athletic | - | Drogheda United | 1:1 | ||||
| 10. Round | 15/04/2022 | Shamrock Rovers | - | St Patrick's Athletic | 1:0 | ||||
| 11. Round | 18/04/2022 | UC Dublin | - | St Patrick's Athletic | 1:2 | ||||
| 12. Round | 22/04/2022 | St Patrick's Athletic | - | Finn Harps | 2:0 | ||||
| 13. Round | 29/04/2022 | St Patrick's Athletic | - | Derry City | 0:4 | |
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| 16. Round | 20/05/2022 | St Patrick's Athletic | - | Shelbourne FC | 1:2 | ||||
| 20. Round | 17/06/2022 | St Patrick's Athletic | - | UC Dublin | 2:1 | ||||
| 19. Round | 27/06/2022 | St Patrick's Athletic | - | Shamrock Rovers | 1:2 | ||||
| 22. Round | 01/07/2022 | St Patrick's Athletic | - | Drogheda United | 3:0 |
Northern Ireland