| 3. Round | 24/07/2022 | Cúcuta Deportivo | - | Barranquilla FC | 0:1 | ||||
| 7. Round | 13/08/2022 | Bogotá FC | - | Barranquilla FC | 1:0 | ||||
| 8. Round | 20/08/2022 | Barranquilla FC | - | Deportes Quindío | 1:1 | ||||
| 11. Round | 07/09/2022 | Fortaleza FC | - | Barranquilla FC | 3:0 | ||||
| 13. Round | 20/09/2022 | Atlético FC | - | Barranquilla FC | 3:2 | ||||
| 14. Round | 24/09/2022 | Barranquilla FC | - | Real Cartagena | 2:3 | ||||
| 15. Round | 01/10/2022 | Valledupar FC | - | Barranquilla FC | 0:1 | ||||
| 16. Round | 08/10/2022 | Barranquilla FC | - | Orsomarso SC | 2:0 |
Colombia