| 1. Round | 10/07/2022 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
| 9. Round | 28/08/2022 | Club Deportivo Ocotal | - | Juventus Managua | 2:2 | ||||
| 11. Round | 11/09/2022 | Real Estelí FC | - | Club Deportivo Ocotal | 5:0 | ||||
| 15. Round | 30/10/2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 2:0 | ||||
| 16. Round | 13/11/2022 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:3 | ||||
| 17. Round | 27/11/2022 | Club Deportivo Ocotal | - | CD Walter Ferretti | 1:1 | ||||
| 18. Round | 30/11/2022 | Juventus Managua | - | Club Deportivo Ocotal | 9:0 |
Nicaragua