| 1. Round | 05/02/2022 | Alianza Lima | - | Atlético Grau | 1:1 | ||||
| 2. Round | 13/02/2022 | Sport Boys | - | Alianza Lima | 0:0 | ||||
| 3. Round | 20/02/2022 | Alianza Lima | - | Mannucci | 3:1 |  |
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| 5. Round | 06/03/2022 | Alianza Lima | - | Sporting Cristal | 0:1 |  |
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| 6. Round | 12/03/2022 | FBC Melgar | - | Alianza Lima | 1:0 | ||||
| 9. Round | 10/04/2022 | Alianza Lima | - | Universidad Técnica | 1:0 | ||||
| 10. Round | 17/04/2022 | Universitario de Deportes | - | Alianza Lima | 1:4 |  |
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| 11. Round | 23/04/2022 | Academia Cantolao | - | Alianza Lima | 1:2 | |
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| 12. Round | 01/05/2022 | Alianza Lima | - | Carlos Stein | 5:2 | |
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| 14. Round | 15/05/2022 | Alianza Lima | - | Universidad Cesar Vallejo | 2:0 | ||||
| 15. Round | 22/05/2022 | Deportivo Municipal | - | Alianza Lima | 0:3 | ||||
| 17. Round | 19/06/2022 | Deportivo Binacional | - | Alianza Lima | 1:0 | ||||
| 18. Round | 27/06/2022 | Alianza Lima | - | Ayacucho FC | 2:0 | ||||
| 19. Round | 03/07/2022 | AD Tarma | - | Alianza Lima | 1:1 |
Peru