| 1. Round | 18/01/2009 | Monarcas Morelia | - | Club San Luis | 0:0 | ||||
| 2. Round | 24/01/2009 | Club San Luis | - | CF Pachuca | 1:2 | ||||
| 3. Round | 31/01/2009 | Jaguares Chiapas | - | Club San Luis | 1:2 |  |
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| 4. Round | 07/02/2009 | Club San Luis | - | Atlas Guadalajara | 2:1 | |
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| 5. Round | 15/02/2009 | UANL Tigres | - | Club San Luis | 1:0 | ||||
| 6. Round | 19/02/2009 | Cruz Azul | - | Club San Luis | 2:2 |  |
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| 7. Round | 21/02/2009 | Club San Luis | - | Atlante | 1:1 | ||||
| 10. Round | 15/03/2009 | Puebla FC | - | Club San Luis | 2:1 | ||||
| 12. Round | 05/04/2009 | Deportivo Guadalajara | - | Club San Luis | 1:0 | ||||
| 13. Round | 11/04/2009 | Club San Luis | - | UAG Tecos | 3:3 | ||||
| 14. Round | 18/04/2009 | CF Monterrey | - | Club San Luis | 1:0 | ||||
| 15. Round | 25/04/2009 | Club San Luis | - | Club Necaxa | 1:1 | ||||
| 16. Round | 03/05/2009 | Santos Laguna | - | Club San Luis | 3:1 |  |
Colombia