| 1. Round | 08/08/2021 | Vida | - | Lobos UPNFM | 1:1 | ||||
| 7. Round | 04/09/2021 | Lobos UPNFM | - | Victoria | 3:0 | ||||
| 10. Round | 19/09/2021 | Lobos UPNFM | - | Motagua | 2:2 |  |
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| 11. Round | 26/09/2021 | Platense | - | Lobos UPNFM | 2:3 | |
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| 12. Round | 03/10/2021 | Lobos UPNFM | - | Marathón | 1:1 | ||||
| 13. Round | 10/10/2021 | Lobos UPNFM | - | Vida | 0:0 | ||||
| 14. Round | 17/10/2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | ||||
| 18. Round | 10/11/2021 | Victoria | - | Lobos UPNFM | 1:0 |
Honduras