| 1. Round | 21/01/2023 | Lobos UPNFM | - | Motagua | 2:1 |  |
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| 2. Round | 25/01/2023 | Real Sociedad | - | Lobos UPNFM | 1:1 |  |
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| 3. Round | 29/01/2023 | Honduras Progreso | - | Lobos UPNFM | 0:2 | ||||
| 4. Round | 01/02/2023 | Lobos UPNFM | - | Victoria | 1:0 | ||||
| 5. Round | 05/02/2023 | Olancho FC | - | Lobos UPNFM | 4:1 | |
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| 6. Round | 11/02/2023 | Lobos UPNFM | - | Marathón | 2:1 | ||||
| 7. Round | 16/02/2023 | Lobos UPNFM | - | Real España | 1:1 | ||||
| 8. Round | 19/02/2023 | Olimpia | - | Lobos UPNFM | 4:1 | |
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| 9. Round | 25/02/2023 | Lobos UPNFM | - | Vida | 3:0 | ||||
| 10. Round | 02/03/2023 | Motagua | - | Lobos UPNFM | 4:3 | ||||
| 11. Round | 05/03/2023 | Lobos UPNFM | - | Real Sociedad | 1:1 | ||||
| 12. Round | 11/03/2023 | Lobos UPNFM | - | Honduras Progreso | 4:2 | |
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| 14. Round | 02/04/2023 | Lobos UPNFM | - | Olancho FC | 1:0 | |
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| 15. Round | 06/04/2023 | Marathón | - | Lobos UPNFM | 1:1 | |
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| 16. Round | 17/04/2023 | Real España | - | Lobos UPNFM | 3:1 | |
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| 17. Round | 24/04/2023 | Lobos UPNFM | - | Olimpia | 1:2 | ||||
| 18. Round | 29/04/2023 | Vida | - | Lobos UPNFM | 2:1 |
Honduras