| 1. Round | 18/01/2025 | Lobos UPNFM | - | Olimpia | 0:1 | ||||
| 3. Round | 29/01/2025 | Juticalpa | - | Lobos UPNFM | 1:0 | ||||
| 4. Round | 04/02/2025 | Lobos UPNFM | - | Victoria | 1:1 | ||||
| 5. Round | 07/02/2025 | Motagua | - | Lobos UPNFM | 5:0 |  |
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| 6. Round | 13/02/2025 | Lobos UPNFM | - | Real España | 3:4 | ||||
| 7. Round | 17/02/2025 | Real Sociedad | - | Lobos UPNFM | 1:1 |  |
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| 8. Round | 22/02/2025 | Lobos UPNFM | - | Olancho FC | 1:1 | ||||
| 9. Round | 01/03/2025 | Marathón | - | Lobos UPNFM | 3:3 | |
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| 10. Round | 06/03/2025 | Olimpia | - | Lobos UPNFM | 2:0 | ||||
| 11. Round | 12/03/2025 | Lobos UPNFM | - | Deportivo Génesis | 1:1 | |
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| 12. Round | 29/03/2025 | Lobos UPNFM | - | Juticalpa | 1:0 | |
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| 13. Round | 03/04/2025 | Victoria | - | Lobos UPNFM | 0:0 | ||||
| 14. Round | 08/04/2025 | Lobos UPNFM | - | Motagua | 2:1 | |
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| 16. Round | 20/04/2025 | Lobos UPNFM | - | Real Sociedad | 2:1 | |
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| 17. Round | 28/04/2025 | Olancho FC | - | Lobos UPNFM | 3:2 | |
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| 18. Round | 04/05/2025 | Lobos UPNFM | - | Marathón | 0:0 |
Honduras