| 1. Round | 12/08/2021 | Balzan FC | - | Sliema Wanderers | 1:0 | ||||
| 3. Round | 11/09/2021 | Gżira United | - | Sliema Wanderers | 1:1 | ||||
| 4. Round | 19/09/2021 | Sliema Wanderers | - | Gudja United | 2:3 | ||||
| 7. Round | 24/10/2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 | ||||
| 8. Round | 31/10/2021 | Sliema Wanderers | - | Mosta FC | 2:3 | ||||
| 9. Round | 20/11/2021 | Sliema Wanderers | - | Valletta FC | 0:3 dec. | ||||
| 10. Round | 27/11/2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 |  |
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| 11. Round | 05/12/2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 | ||||
| 13. Round | 19/12/2021 | Floriana FC | - | Sliema Wanderers | 2:0 | ||||
| 14. Round | 18/01/2022 | Sliema Wanderers | - | Gżira United | 1:3 | |
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| 12. Round | 26/01/2022 | Sliema Wanderers | - | Balzan FC | 1:0 | ||||
| 16. Round | 29/01/2022 | Sliema Wanderers | - | Sirens FC | 1:0 | ||||
| 17. Round | 05/02/2022 | Hibernians FC | - | Sliema Wanderers | 1:0 | ||||
| 20. Round | 26/02/2022 | Valletta FC | - | Sliema Wanderers | 1:0 | ||||
| 21. Round | 06/03/2022 | Sliema Wanderers | - | Birkirkara FC | 0:0 | ||||
| 22. Round | 11/03/2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 | |
Malta