| 1. Round | 13/08/2021 | Cefn Druids | - | Connah's Quay Nomads | 0:2 | ||||
| 2. Round | 21/08/2021 | Flint Town United | - | Cefn Druids | 4:0 | ||||
| 4. Round | 31/08/2021 | Newtown AFC | - | Cefn Druids | 5:0 | ||||
| 5. Round | 10/09/2021 | Caernarfon Town | - | Cefn Druids | 3:0 | ||||
| 6. Round | 18/09/2021 | Cefn Druids | - | Penybont FC | 0:3 |  |
Wales