| 1. Round | 13/03/2021 | MŠK Žilina | - | Spartak Trnava | 2:1 | ||||
| 2. Round | 21/03/2021 | Spartak Trnava | - | FC DAC 1904 | 3:2 | ||||
| 3. Round | 03/04/2021 | AS Trenčín | - | Spartak Trnava | 0:1 | ||||
| 4. Round | 10/04/2021 | Spartak Trnava | - | Zlaté Moravce | 3:0 | ||||
| 5. Round | 17/04/2021 | Slovan Bratislava | - | Spartak Trnava | 1:2 |  |
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| 6. Round | 24/04/2021 | Spartak Trnava | - | AS Trenčín | 2:0 | |
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| 7. Round | 02/05/2021 | Spartak Trnava | - | Slovan Bratislava | 3:0 | |
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| 8. Round | 08/05/2021 | Zlaté Moravce | - | Spartak Trnava | 0:0 | ||||
| 9. Round | 16/05/2021 | Spartak Trnava | - | MŠK Žilina | 1:1 | ||||
| 10. Round | 22/05/2021 | FC DAC 1904 | - | Spartak Trnava | 2:0 |
Slovakia